FTS Products

Description

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

Bioinformatics

Entrez	64400 Human
Uniprot	NP_071921 Human
Product By Gene ID	64400
Alternate Names	AKT interacting protein AKT-interacting protein FLJ13258 Ft1 FTSfused toes homolog (mouse) fused toes (mouse) homolog fused toes homolog Fused toes protein homolog

Research Areas for FTS

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Apoptosis