FPGT Products

Description

L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose.

Bioinformatics

Entrez	8790 Human
Uniprot	NP_003829 Human NP_003829.2 Human O14772 Human
Product By Gene ID	8790
Alternate Names	fucose-1-phosphate guanyltransferase fucose-1-phosphate guanylyltransferase GDP-beta-L-fucose pyrophosphorylase GDP-L-fucose diphosphorylase GDP-L-fucose pyrophosphorylase GFPPEC 2.7.7.30