FOXO4 Products

Description

AFX aka FOXO4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.

Bioinformatics

Product By Gene ID	4303
Alternate Names	AFX AFX1myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog);translocated to, 7 Fork head domain transcription factor AFX1 forkhead box O4 forkhead box protein O4 MLLT7MGC120490 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);translocated to, 7

Research Areas for FOXO4

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Cell Cycle and Replication

Related FOXO4 Blog Posts

Check out the latest blog posts on FOXO4.

The role of HIF-1 Alpha signaling in the retina under hypoxic conditions Hypoxia inducible factor 1 (HIF-1) is a protein that plays an essential role in hypoxia, or low levels of cellular oxygen. HIF-1 is a heterodimeric protein that consists of a constitutively expressed beta subunit and oxygen related alpha subunit.  ...    Read more.

The Wise Old Fox: Forkhead Transcription Factors and Age-Related DAF-16 Studies Orthologs are one of the classes of homolog genes. They occur in different species, but are linked by a common ancestral pathway. During evolution, they retain the same original function, irrespective of the species. Among the orthologs covered on our...    Read more.

Read more FOXO4 related blogs.