FKBP12 Products

Antibodies
FKBP12 Antibody (422513)
FKBP12 Antibody (422513)
MAB3777
Species: Hu, Mu, Rt
Applications: WB
Host: Rat Monoclonal
FKBP12 Antibody
FKBP12 Antibody
NB300-508
Species: Hu, Mu, Rt, Po
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
FKBP12 Antibody (3B3)
FKBP12 Antibody (3B3)
NBP2-02093
Species: Hu
Applications: WB, Flow, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
FKBP12 Overexpression Lysate ...
FKBP12 Overexpression Lysate (Native)
NBL1-10732
Applications: WB
FKBP12 Overexpression Lysate ...
FKBP12 Overexpression Lysate (Native)
NBL1-10733
Applications: WB
Proteins
Recombinant Human FKBP12 Prot ...
Recombinant Human FKBP12 Protein
H00002280-P01
Species: Hu, Mu
Applications: WB, ELISA, PA
Recombinant Human FKBP12 Prot ...
Recombinant Human FKBP12 Protein
NBC1-21651
Species: Hu
Applications: Func, PAGE
FKBP12 Recombinant Protein An ...
FKBP12 Recombinant Protein Antigen
NBP2-14017PEP
Species: Hu
Applications: AC
RNAi
FKBP12 RNAi
FKBP12 RNAi
H00002280-R03
Species: Hu
Applications: RNAi, RNAi SP
FKBP12 RNAi
FKBP12 RNAi
H00002280-R04
Species: Hu
Applications: RNAi, RNAi SP

Description

Immunophilins are a family of soluble receptors capable of binding to one of two major immunosuppressant agents; cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Immunophilins function as cis-trans peptidyl-prolyl isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. Thus, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline-containing proteins.FKBP12:FK506 complexes inhibit calcineurin, a calcium/calmodulin-dependent serine/threonine phosphatase which blocks T-cell activation by preventing lymphokine gene transcription. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. In interactions with members of the TGF beta family type I receptors, FKBP12 has been shown to exert an inhibitory effect on the signaling pathway.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 2280
Alternate Names
  • FK506-binding protein 1A
  • EC 5.2.1.8
  • Rotamase
  • PPIase FKBP1A
  • rotamase
  • FKBP1
  • protein kinase C inhibitor 2
  • FKBP-1A
  • peptidyl-prolyl cis-trans isomerase FKBP1A
  • 12 kDa FKBP
  • FKBP-12T-cell, 12-kD
  • FKBP12FKBP12-Exip3
  • FKBP12C
  • FK506 binding protein 1A, 12kDa

Research Areas for FKBP12

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
mTOR Pathway

Bioinformatics Tool for FKBP12

Discover related pathways, diseases and genes to FKBP12. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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