Fibrillarin Products

Antibodies
Fibrillarin Antibody (38F3)
Fibrillarin Antibody (38F3)
Species: Hu, Mu, Rt, Ce, Ch, Dr, Pl, Ye
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IHC-WhMt
Host: Mouse Monoclonal
Fibrillarin Antibody
Fibrillarin Antibody
NBP2-16492
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IP
Host: Rabbit Polyclonal
Fibrillarin Antibody
Fibrillarin Antibody
NBP2-46881
Species: Hu
Applications: WB, ICC/IF
Host: Chicken Polyclonal
Lysates
Fibrillarin Overexpression Ly ...
Fibrillarin Overexpression Lysate ...
NBL1-10607
Species: Hu
Applications: WB
Proteins
Fibrillarin Recombinant Prote ...
Fibrillarin Recombinant Protein An...
NBP2-58592PEP
Species: Hu
Applications: AC
Recombinant Human Fibrillarin ...
Recombinant Human Fibrillarin Protein
NBP1-48594
Species: Hu
Applications: PAGE
RNAi
Fibrillarin RNAi
Fibrillarin RNAi
H00002091-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Nop1p / Fibrillarin was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae (accession P15646). The Nop1p protein is essential for yeast viability and is localized in the nucleoli. The human homologue of Nop1p is fibrillarin (accession P22087) a component of the nucleolar small nuclear ribonucleoprotein (snRNP) particle. The human fibrillarin gene is located on chromosome 19 (19q13.1). Fibrillarin proteins have been cloned and sequenced from several other species (Mouse, accession P35550, Xenopus accession P22232, C. elegans accession Q22053, and S. pombe accession P35551). The N terminal 80 amino acids contain multiple copies based on the peptide RGG, and the remaining 240 amino acids consist of the fibrillarin domain. A fibrillarin homologue has also been identified in the genome of the archean Methanococcus (accession NC_000909). This protein lacks the RGG rich N-terminal extension but is clearly homologous to the other sequences throughout all of the fibrillarin domain. The structure of this molecule has been determined and shown to consist of 2 extended beta-sheets flanked by 4 alpha-helixes. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to a 34kDa protein which was subsequently found to be fibrillarin. Fibrillarin is an excellent marker for the nucleolus.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 2091
Alternate Names
  • EC 2.1.1.37
  • EC 2.1.1,34-kD nucleolar scleroderma antigen
  • FIB1,34 kDa nucleolar scleroderma antigen
  • RNU3IP1
  • EC 2.1.1.-
  • FIB
  • FLRNrRNA 2'-O-methyltransferase fibrillarin
  • RNA, U3 small nucleolar interacting protein 1
  • fibrillarin

Research Areas for Fibrillarin

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
Core ESC-Like Genes
Neuroscience
Nuclear Envelope Markers
Stem Cell Markers

Bioinformatics Tool for Fibrillarin

Discover related pathways, diseases and genes to Fibrillarin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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