FGD1 Products

Description

FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.

Bioinformatics

Entrez	2245 Human
Uniprot	NP_004454.2. Human
Product By Gene ID	2245
Alternate Names	faciogenital dysplasia (Aarskog-ScRhoGEF and PH domain-containing protein 1 Faciogenital dysplasia 1 protein FGDYMRXS16 FYVE, RhoGEF and PH domain containing 1 Rho/Rac guanine nucleotide exchange factor FGD1 ZFYVE3AAS Zinc finger FYVE domain-containing protein 3

Research Areas for FGD1

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Cytoskeleton Markers
GPCR
Signal Transduction