CD16 (FcgRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgRIII is expressed in two forms FcgRIII-A and -B. FcgRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FceRI-g subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgRIII-A is associated, moreover, with FceRI-b subunit. Besides IgG, FceRI-A can be triggered also by oligomeric IgE. FcgRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.
|Product By Gene ID
- CD16b antigen
- IgG Fc receptor III-1
- Fc-gamma RIIIb
- Fc-gamma RIII-beta
- low affinity immunoglobulin gamma Fc region receptor III-B
- Fc-gamma RIII
- Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
- Fc-gamma receptor IIIb (CD 16)
- Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Bioinformatics Tool for Fc gamma RIIIB/CD16b
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