Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, PA, AP
Species: Hu
Applications: AC
Description
F-box/SPRY domain-containing protein 1, also known as F-box only protein 45 and FBXO45, is a component of the E3 ubiquitin ligase complex. FBXO45 is required for normal neuromuscular synaptogenesis, neuronal migration and axon pathfinding. FBXO45 also plays a role in regulating neurotransmission by mature neurons and controlling synaptic activity via UNC13A in the ubiquitin dependent pathway. FBXO45 protein recognizes TP73 and promotes it ubiquitination and degradation. FBXO45 expression is down regulated in response to DNA damage.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
200933 |
| Alternate Names |
- F-box/SPRY domain-containing protein 1
- FBX45
- F-box only protein 45
- Fbx45
- F-box protein 45
|
Bioinformatics Tool for FBXO45
Discover related pathways, diseases and genes to FBXO45. Need help? Read the
Bioinformatics Tool Guide for instructions on using this tool.
