FBXO45 Products


Description

F-box/SPRY domain-containing protein 1, also known as F-box only protein 45 and FBXO45, is a component of the E3 ubiquitin ligase complex. FBXO45 is required for normal neuromuscular synaptogenesis, neuronal migration and axon pathfinding. FBXO45 also plays a role in regulating neurotransmission by mature neurons and controlling synaptic activity via UNC13A in the ubiquitin dependent pathway. FBXO45 protein recognizes TP73 and promotes it ubiquitination and degradation. FBXO45 expression is down regulated in response to DNA damage.

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 200933
Alternate Names
  • F-box only protein 45
  • F-box protein 45
  • F-box/SPRY domain-containing protein 1
  • FBX45
  • Fbx45