FBXO45 Products

Description

F-box/SPRY domain-containing protein 1, also known as F-box only protein 45 and FBXO45, is a component of the E3 ubiquitin ligase complex. FBXO45 is required for normal neuromuscular synaptogenesis, neuronal migration and axon pathfinding. FBXO45 also plays a role in regulating neurotransmission by mature neurons and controlling synaptic activity via UNC13A in the ubiquitin dependent pathway. FBXO45 protein recognizes TP73 and promotes it ubiquitination and degradation. FBXO45 expression is down regulated in response to DNA damage.

Bioinformatics

Entrez	200933 Human
Uniprot	P0C2W1 Human
Product By Gene ID	200933
Alternate Names	F-box/SPRY domain-containing protein 1 FBX45 F-box only protein 45 Fbx45 F-box protein 45

Diseases related to FBXO45

Discover more about diseases related to FBXO45.

Nervousness
Sclerosis
Neuroblastoma
Cell Transformation, Neoplastic
Neoplasms
Mammary Neoplasms
Tuberous Sclerosis
Respiratory Distress

Pathways for FBXO45

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Cell Cycle
Cell Death
Innervation

PTMs for FBXO45

Learn more about PTMs related to FBXO45.

Ubiquitination
Phosphorylation
Acetylation

Bioinformatics Tool for FBXO45

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