FANCG Products

Description

FANCG (also called Protein FACG or DNA-repair protein XRCC9) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCG may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. This protein may also function as a tumor suppressor gene. FANCG belongs to the multi-subunit Fanconi Anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes. The putative 622-amino acid protein has a leucine-zipper motif at its N-terminus. FANCG is mainly found within the nucleus although some protein is localized in the cytoplasm. This protein is highly expressed in testis and thymus and is also found in lymphoblasts. Fanconi anemia is an autosomal recessive disorder with diverse clinical symptoms, including developmental anomalies, bone marrow failure, and early occurrence of malignancies caused by defects in the FANCG gene. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.

Bioinformatics

Entrez	2189 Human
Uniprot	O15287 Human
Product By Gene ID	2189
Alternate Names	DNA repair protein XRCC9 FAG FANCG Fanconi anemia group G protein Fanconi anemia, complementation group G Protein FACG X-ray repair, complementing defective, in Chinese hamster, 9 XRCC9 XRCC9X-ray repair complementing defective repair in Chinese hamster cells 9

Research Areas for FANCG

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
DNA Repair
Genes Sensitive to DNA Damaging Agents

Related FANCG Blog Posts

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Fanconi Antibodies and Cancer Research We at Novus Biologicals have an extensive antibody databasedevoted to the 13 Fanconi anaemia complementation (FANC) genes, which are involved in the recognition and repair of damaged DNA.The core complex of 8 proteins (FANCA, B, C, E, F, G, L and M)...    Read more.

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