ERp57/PDIA3 Products

Antibodies
ERp57/PDIA3 Antibody (CL2444) ...
ERp57/PDIA3 Antibody (CL2444)
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC
Host: Mouse Monoclonal
ERp57/PDIA3 Antibody
ERp57/PDIA3 Antibody
NBP1-84796
Species: Hu, Mu, Rt, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
ERp57/PDIA3 Antibody
ERp57/PDIA3 Antibody
Species: Hu, Mu, Rt, Bovine, Porcine, Sheep, Rhesus Macaque, Monkey
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
ERp57/PDIA3 Antibody Pair
ERp57/PDIA3 Antibody Pair
H00002923-PW1
Species: Hu
Applications: WB, IP
Lysates
ERp57/PDIA3 Overexpression Ly ...
ERp57/PDIA3 Overexpression Lysate ...
H00002923-T01
Species: Hu
Applications: WB
ERp57/PDIA3 Overexpression Ly ...
ERp57/PDIA3 Overexpression Lysate ...
NBL1-14244
Applications: WB
Proteins
ERp57/PDIA3 Partial Recombina ...
ERp57/PDIA3 Partial Recombinant Pr...
H00002923-Q01
Species: Hu
Applications: WB, ELISA, PA
ERp57/PDIA3 Recombinant Prote ...
ERp57/PDIA3 Recombinant Protein
H00002923-P01
Species: Hu
Applications: WB, ELISA, PA
ERp57/PDIA3 Recombinant Prote ...
ERp57/PDIA3 Recombinant Protein An...
NBP1-84797PEP
Species: Hu
Applications: AC

Description

ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glucosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface (6). ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus (7).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 2923
Alternate Names
  • p58
  • Endoplasmic reticulum resident protein 57
  • ERP60
  • Disulfide isomerase ER-60
  • ERP57
  • protein disulfide isomerase-associated 3
  • protein disulfide-isomerase A3
  • glucose regulated protein, 58kDa
  • phospholipase C-alpha
  • PI-PLC
  • endoplasmic reticulum P58
  • P58
  • ER60
  • HsT17083
  • EC 5.3.4.1
  • GRP57
  • ER protein 60
  • ERp61
  • GRP58ER protein 57
  • ERp6058 kDa microsomal protein
  • ERp5758 kDa glucose-regulated protein
  • Endoplasmic reticulum resident protein 60
  • protein disulfide isomerase family A, member 3

Research Areas for ERp57/PDIA3

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
ER Markers
Membrane Trafficking and Chaperones

Bioinformatics Tool for ERp57/PDIA3

Discover related pathways, diseases and genes to ERp57/PDIA3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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