ERK3/MAPK6 Products

Description

ERK3 (Extracellular signal-regulated kinase 3, MAPK6, p97 MAPK) belongs to the Ser/Thr protein kinase family and is a member of the mitogen-activated protein (MAP) kinase superfamily. Unlike the other members of the MAPK family, ERK3 is a mitogen-activated protein kinase homologue that has SEG motif instead of conserved TXY motif in the activation loop (1). Also, unlike ERK1 and ERK2, it is ubiquitously expressed and localized in the nucleus of proliferating cells (2). Highly unstable, ERK3 is constitutively degraded during ubiquitin-proteasome pathway of proliferating cells (3). ERK3 has been linked to phosphorylation MAP2 and as a possible regulator during cell differentiation (4).

Bioinformatics

Entrez	5597 Human 58840 Rat
Uniprot	AAH35492 Human NM_002748 Human NP_002739.1 Human Q16659 Human
Product By Gene ID	5597
Alternate Names	DKFZp686F03189 EC 2.7.11 EC 2.7.11.24 ERK-3 ERK3p97-MAPK Extracellular signal-regulated kinase 3 extracellular signal-regulated kinase, p97 HsT17250 MAP kinase 6 MAP kinase isoform p97 MAPK 6 mitogen-activated protein kinase 6 p97MAPK PRKM6 protein kinase, mitogen-activated 5 protein kinase, mitogen-activated 6

Research Areas for ERK3/MAPK6

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