ERK1/2 Products

Description

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and Threonine sites mapping within a characteristic Thr- Glu-Tyr motif. Phosphorylation at both the Thr and Tyr residues is required for full enzymatic activation. In response to activation, MAP kinases phos-phorylate downstream components on Serine and Threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.

Bioinformatics

Entrez	5595 Human 50689 Rat
Uniprot	P27361
Product By Gene ID	5595
Alternate Names	EC 2.7.11 ERK-1 ERK1p44-MAPK ERT2 Extracellular signal-regulated kinase 1 extracellular signal-related kinase 1 HS44KDAP HUMKER1A Insulin-stimulated MAP2 kinase MAP kinase 1 MAP kinase 3 MAP kinase isoform p44 MAPK 1 MAPK 3 MGC20180 Microtubule-associated protein 2 kinase Mitogen-activated protein kinase 1 mitogen-activated protein kinase 3 P44ERK1 p44-ERK1 P44MAPK PRKM3EC 2.7.11.24

Research Areas for ERK1/2

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Breast Cancer
Cancer
Cell Cycle and Replication
Diabetes Research
Hypoxia
MAP Kinase Signaling
Signal Transduction

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SUCNR1/GPR91 - a potential role in renovascular hypertension SUCNR1 is the cognate receptor for the Kreb's citric acid cycle intermediate succinate. It is of interest to scientists because it is involved in not only energy metabolism but possibly also in renovascular hypertension, a condition linked to diabe...    Read more.

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