eIF4E Products

Description

eIF-4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It exists in two forms: as a free form (25 kDa) and as part of a multiprotein complex eIF-4F (1). eIF-4E appears to be the least abundant of the initiation factors and acts as a rate-limiting step of initiation (2). Since translation is regulated by phosphorylation, eIF-4E phosphorylation at Ser 209 by MAPK signal-integrating kinase 1 (Mnk1) and kinase 2 (Mnk2) may directly regulate the rate of protein synthesis initiation (3). There is also evidence that eIF-4E can function as an oncogene (4-5).

Bioinformatics

Entrez	117045 Rat 13684 Mouse 1977 Human
Uniprot	AAH12611 Human AAH35166.1 Human NM_001968 Human NP_001959 Human NP_001959.1 Human P06730 Human
Product By Gene ID	1977
Alternate Names	CBP eIF4E eIF-4E EIF4E1 EIF4EL1MGC111573 eIF-4F 25 kDa subunit EIF4F eukaryotic translation initiation factor 4E eukaryotic translation initiation factor 4E-like 1 mRNA cap-binding protein

Research Areas for eIF4E

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
DNA replication, Transcription, Translation and Splicing
mTOR Pathway
Phospho-Specific