E2F5 Products

Description

The protein encoded by the E2F5 gene is a member of the E2F family of transcription factors. The E2F family plays a crucialrole in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transformingproteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that arepresent in most members of the family. These domains include a DNA binding domain, a dimerization domain whichdetermines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domainenriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within thetransactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of humantissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumorsuppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encodingdifferent isoforms. (provided by RefSeq)

Bioinformatics

Entrez	1875 Human 13559 Mouse 116651 Rat
Uniprot	NP_001942 Human Q15329 Human
Product By Gene ID	1875
Alternate Names	transcription factor E2F5 E2F-5 E2F transcription factor 5, p130-binding

Diseases related to E2F5

Discover more about diseases related to E2F5.

Neoplasms
Retinoblastoma
Malignant Neoplasms
Carcinoma
Hyperplasia
Malignant Neoplasm Of Breast
Growth Arrest
Mammary Neoplasms
Cell Transformation, Neoplastic
Malignant Neoplasm Of Ovary
Malignant Paraganglionic Neoplasm
Melanoma
Ovarian Neoplasm
Prostatic Neoplasms
Hypertrophy
Malignant Neoplasm Of Prostate
Skin Neoplasms
Hydrocephalus
Malignant Neoplasm Of Lung
Cell Invasion

Pathways for E2F5

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Cell Cycle
Cell Proliferation
S Phase
Cell Growth
Cell Cycle Arrest
Localization
Cell Death
G1 Phase
Pathogenesis
Regeneration
Dna Replication
Regulation Of Gene Expression
Cell Differentiation
Keratinocyte Differentiation
Induction Of Apoptosis
Mitosis
Senescence
Keratinocyte Proliferation
Nuclear Export
Cell Division

Research Areas for E2F5

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Cell Cycle and Replication

PTMs for E2F5

Learn more about PTMs related to E2F5.

Phosphorylation
Cleavage
Dephosphorylation
Methylation
Ubiquitination
Phosphorothionation
Acetylation

Bioinformatics Tool for E2F5

Discover related pathways, diseases and genes to E2F5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.