Dystrophin Products

Antibodies
Dystrophin Antibody (MANDRA1) ...
Dystrophin Antibody (MANDRA1)
NB120-7164
Species: Hu, Mu, Rt, Fi
Applications: ELISA, ICC/IF, MiAr
Host: Mouse Monoclonal
Dystrophin Antibody
Dystrophin Antibody
NBP1-89953
Species: Hu, Mu, Rat
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Dystrophin Antibody (1808)
Dystrophin Antibody (1808)
NB120-3149
Species: Hu, Mu, Rt, Ch, Xp
Applications: IHC, IHC-P
Host: Mouse Monoclonal
Antibody Pairs
Dystrophin Antibody Pair
Dystrophin Antibody Pair
H00001756-PW1
Species: Hu
Applications: WB, IP
Lysates
Dystrophin Overexpression Lys ...
Dystrophin Overexpression Lysate (...
NBP2-10564
Applications: WB
Dystrophin Overexpression Lys ...
Dystrophin Overexpression Lysate (...
NBP2-10565
Applications: WB
Dystrophin Overexpression Lys ...
Dystrophin Overexpression Lysate (...
H00001756-T01
Species: Hu
Applications: WB
Proteins
Dystrophin Recombinant Protei ...
Dystrophin Recombinant Protein
H00001756-P01
Species: Hu
Applications: WB, ELISA, PA
Dystrophin Recombinant Protei ...
Dystrophin Recombinant Protein Ant...
NBP1-89954PEP
Species: Hu
Applications: AC
Dystrophin Recombinant Protei ...
Dystrophin Recombinant Protein Ant...
NBP1-89953PEP
Species: Hu
Applications: AC
RNAi
Dystrophin RNAi
Dystrophin RNAi
H00001756-R08
Species: Hu
Applications: RNAi, RNAi SP
Dystrophin RNAi
Dystrophin RNAi
H00001756-R18
Species: Hu
Applications: RNAi, RNAi SP
Dystrophin RNAi
Dystrophin RNAi
H00001756-R05
Species: Hu
Applications: RNAi, RNAi SP

Description

Dystrophin is a muscle membrane protein (427 kDa) which is absent, reduced or altered as a result of mutation in Duchenne and Becker muscular dystrophies (DMD/BMD) or its homologue in the mouse.8 Severe DMD is associated with a marked dystrophin deficiency whereas patients with the milder form of BMD show less pronounced abnormalities of protein expression. Because abnormalities in the protein expression occur specifically in patients with these types of muscular dystrophy, dystrophin analysis may be used to distinguish these conditions from other neuromuscular diseases. Predictions from the sequence suggest a structural protein on the inner face of the membrane, consisting of a 25-repeat, rod-like triple-helical domain separating an N-terminal actin-binding domain from two C-terminal domains, one of which is rich in cysteine.9 The large size of dystrophin and its low abundance (<0.01% of the total muscle protein) are a hindrance to the isolation of intact, native protein for structure/function studies. Monoclonal antibodies against defined regions10 of dystrophin provide a means for studying its structure and function, interactions with other proteins and the nature of the partial gene products produced in some patients carrying deletions in the dystrophin gene. The antibodies are useful in the prenatal or post-abortion diagnosis of muscular dystrophy carriers by immunohistological analyses.11

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 1756
Alternate Names
  • DXS269
  • DXS268
  • DXS239
  • DXS230
  • DXS206
  • DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272
  • dystrophin (muscular dystrophy, Duchenne and Becker types), includes DXS142
  • DXS164
  • CMD3B
  • DXS142
  • BMDDXS272
  • DXS270
  • dystrophin

Research Areas for Dystrophin

Find related products by research area and learn more about each of the different research areas below.

Cytoskeleton Markers

Bioinformatics Tool for Dystrophin

Discover related pathways, diseases and genes to Dystrophin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Dystrophin Blog Posts

Check out the latest blog posts on Dystrophin.
Could Laminin be Used to Treat Duchenne Muscular Dystrophy?
Duchenne muscular dystrophy (DMD) is a severe muscle wasting condition, causing disability and early death. There is currently no cure or adequate treatment for DMD, but pioneering research indicates that injection of a laminin protein may prevent (or...    Read more.
Read more Dystrophin related blogs.