DUSP4 Products

Description

Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X, and MKP- 4. Human MKP-2 maps to chromosome 8p12-p11 and encodes a 394 amino acid, 43 kDa protein that specifically inactivates ERK1, ERK2 and JNK.

Bioinformatics

Entrez	1846 Human 319520 Mouse 60587 Rat 75590 Mouse
Uniprot	AAH02671 Human NM_001394 Human NM_057158 Human NP_001385 Human NP_001385.1 Human Q13115 Human
Product By Gene ID	1846
Alternate Names	dual specificity phosphatase 4 Dual specificity protein phosphatase hVH2 EC 3.1.3.16 EC 3.1.3.48 HVH2serine/threonine specific protein phosphatase MAP kinase phosphatase 2 Mitogen-activated protein kinase phosphatase 2 MKP-2dual specificity protein phosphatase 4 MKP2VH1 homologous phosphatase 2 TYP VH2

Research Areas for DUSP4

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Cell Cycle and Replication