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DTX1/DTX4 Products


Description

Deltex-1 (DTX1) is an approximately 75 kDa cytoplasmic and nuclear ubiquitin ligase that interacts with the Notch-1 intracellular domain and regulates Notch-induced gene transcription. It contains two WWE domains (aa 14-94 and aa 95-171) and one RING-type zinc finger (aa 411-472). Within aa 1-147, human Deltex-1 shares 97% aa sequence identity with mouse and rat Deltex-1.

Bioinformatics

Uniprot
Q86Y01
Alternate Names
  • DTX1/DTX4
  • DTX1;Fxit1;hDx-1;mKIAA4160