DR1 Products

Description

DR1 encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq]

Bioinformatics

Entrez	1810 Human
Uniprot	AAH02809 Human NM_001938 Human NP_001929 Human NP_001929.1 Human
Product By Gene ID	1810
Alternate Names	Down-regulator of transcription 1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) NC2 NC2-beta NC2-BETA Negative cofactor 2-beta protein Dr1 TATA-binding protein-associated phosphoprotein

Research Areas for DR1

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Stem Cell Markers