DPH3 Products

Description

This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Bioinformatics

Product By Gene ID

285381

Alternate Names

DelGEF-interacting protein 1 DELGIP DelGIP1 DELGIP1deafness locus putative guanine nucleotide exchange factor interacting protein1 DESR1CSL-type zinc finger-containing protein 2 DPH3 homolog (KTI11, S. cerevisiae) DPH3 homolog DPH3, KTI11 homolog (S. cerevisiae) DPH3A DPH3A, KTI11 homolog A KTI11Del-GEF interacting protein MGC20197 ZCSL2diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1 zinc finger, CSL domain containing 2 zinc finger, CSL-type containing 2