DEDD2 Products

Antibodies
DEDD2 Antibody
DEDD2 Antibody
NB100-56137
Species: Hu, Rt, Bv, Ca, Pm
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
DEDD2 Antibody
DEDD2 Antibody
NB100-56138
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
DEDD2 Antibody
DEDD2 Antibody
NBP1-76451
Species: Hu, Mu, Rt
Applications: WB, ELISA
Host: Rabbit Polyclonal
Lysates
DEDD2 Overexpression Lysate ( ...
DEDD2 Overexpression Lysate (Native)
NBL1-09816
Applications: WB
Proteins
DEDD2 Peptide
DEDD2 Peptide
NBP1-76451PEP
Species: Hu
Applications: AC
RNAi
DEDD2 RNAi
DEDD2 RNAi
H00162989-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Apoptosis and inflammation are important cellular processes that are highly regulated through specific protein-protein interactions (PPI). Proteins involved in these signaling cascades often carry PPI domains belonging to the death-domain superfamily (reviewed in Kohl A and MG Grutter, 2004). These PPI domains include the death effector domain (DED), the death domain (DD), the caspase activation and recruitment domain (CARD) and the pyrin domain (PYD). PPI domains are structurally related and comprised of a six alpha helical structure; within proteins PPI domains can be found in isolation or in combination with other domains. DEDD2/Flame-3 (DED containing DNA binding2) belongs to a family of single DED-containing proteins that is targeted to the nucleus (reviewed in Barnhart et al, 2003; Slvibst ry sl, 2003). Several DED-containing proteins are involved in the regulation of apoptosis through their interactions with DED-containing caspases. It is thought that DEDD2 and its closely related homologue DEDD may mediate cell death by binding to the DED-containing caspases -8 and -10, and targeting them to the nucleus following death receptor induced apoptosis. However, the function of DEDD2 and DEDD remain to be fully elucidated, and they may also have roles in cellular processes other than apoptosis. This antibody recognizes DEDD2/Flame-3; human DED2/Flame-3 is a 326 amino acid protein.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 162989
Alternate Names
  • FADD-like apoptotic molecule 3
  • FLAME3
  • DED-containing protein FLAME-3
  • DNA-binding death effector domain-containing protein 2
  • FLAME-3
  • death effector domain-containing DNA binding protein 2
  • death effector domain containing 2

Diseases related to DEDD2

Discover more about diseases related to DEDD2.

Malignant Neoplasms
Neoplasms
Bulla

Pathways for DEDD2

View related products by pathway and learn more about each of the pathways below.

Cell Death
Localization
Sensitization
Cell Proliferation
Programmed Cell Death
Cell Cycle

PTMs for DEDD2

Learn more about PTMs related to DEDD2.

Cleavage
Ubiquitination

Bioinformatics Tool for DEDD2

Discover related pathways, diseases and genes to DEDD2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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