DAZ1 Products

Description

DAZ1 is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two RRM domains.

Bioinformatics

Entrez	1617 Human
Uniprot	NP_001006118.2 Human AAH18119 Human
Product By Gene ID	1617
Alternate Names	deleted in azoospermia SPGYDAZdeleted in azoospermia protein 1 FLJ17175 deleted in azoospermia 1

Diseases related to DAZ1

Discover more about diseases related to DAZ1.

Azoospermia
Oligospermia
Infertility
Male Infertility
Congenital Absence Of Germinal Epithelium Of Testes
Partial Deletion Of Y
Steroid Sulfatase Deficiency Disease
Sex Chromosome Aberrations
Growth Arrest
Sterility
Embryonic Mosaic
Chromosome Inversion
Cytogenetic Abnormality
Klinefelter Syndrome
Spermatogenesis Arrest
De Novo Mutation
Virilism
Gonadoblastoma
Isodicentric Chromosome
Turner Syndrome

Pathways for DAZ1

View related products by pathway and learn more about each of the pathways below.

Spermatogenesis
Meiosis
Localization
Translation
Cell Development
Germ Cell Development
Sex Determination
Fertilization
Oogenesis
Cell Division
Cell Cycle
Interphase
Methylation
Pachytene
Transposition
Gene Conversion
Reverse Transcription
Female Meiosis
Cell Differentiation
Prophase

PTMs for DAZ1

Learn more about PTMs related to DAZ1.

Methylation
Phosphorylation
Cleavage

Bioinformatics Tool for DAZ1

Discover related pathways, diseases and genes to DAZ1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.