Cytokeratin 5 Products

Antibodies
Cytokeratin 5 Antibody (2C2)
Cytokeratin 5 Antibody (2C2)
Species: Hu, Mu, Mk
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Cytokeratin 5 Antibody (2C2B4 ...
Cytokeratin 5 Antibody (2C2B4)
NBP2-37373
Species: Hu
Applications: WB, ELISA, Flow, IHC, IHC-P
Host: Mouse Monoclonal
Cytokeratin 5 Antibody (1E7)
Cytokeratin 5 Antibody (1E7)
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
Antibody Pairs
Cytokeratin 5 Antibody Pair
Cytokeratin 5 Antibody Pair
H00003852-PW1
Species: Hu
Applications: WB, IP
Lysates
Cytokeratin 5 Overexpression ...
Cytokeratin 5 Overexpression Lysat...
NBL1-12393
Applications: WB
Cytokeratin 5 Overexpression ...
Cytokeratin 5 Overexpression Lysat...
H00003852-T01
Applications: WB
Proteins
Cytokeratin 5 Recombinant Pro ...
Cytokeratin 5 Recombinant Protein
H00003852-P01
Species: Hu
Applications: WB, ELISA, PA
Cytokeratin 5 Recombinant Pro ...
Cytokeratin 5 Recombinant Protein ...
NBP2-32470PEP
Species: Hu
Applications: AC
Cytokeratin 5 Recombinant Pro ...
Cytokeratin 5 Recombinant Protein
NBP2-51653
Species: Hu
Applications: PAGE

Description

Keratins are a family of structurally related proteins that form the intermediate filament cytoskeleton in epithelial cells. The 58-kD keratin CK-5 is highly similar to other type II keratins and less similar to type I keratins and other intermediate filament proteins. The 58-kD keratin is regulated by retinoids in several tissues and is one of four keratins abundantly expressed in epidermal keratinocytes, where it may be important in maintaining structural integrity of the integument (1). Keratin 5 (CK-5) mRNA and protein are shown to be expressed in normal mammary epithelial cells in culture and are absent from tumor-derived cell lines. This makes CK-5 an important marker in the tumorigenic process, distinguishing normal from tumor cells, and decreased CK-5 expression correlates with tumorigenic progression (2). Dowling-Degos disease (DDD) is an autosomal dominant genodermatosis characterized by progressive and disfiguring reticulate hyperpigmentation of the flexures. Loss of function of CK-5 suggests a crucial role for keratins in the organization of cell adhesion, melanosome uptake, organelle transport, and nuclear anchorage (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 3852
Alternate Names
  • K5
  • Keratin-5
  • CK-5
  • Cytokeratin-5
  • Type-II keratin Kb5
  • keratin, type II cytoskeletal 5
  • 58 kDa cytokeratin
  • cytokeratin-5
  • keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockaynetypes)
  • EBS2
  • epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types
  • CK5
  • KRT5A
  • DDD
  • keratin 5

Research Areas for Cytokeratin 5

Find related products by research area and learn more about each of the different research areas below.

Cytoskeleton Markers

PTMs for Cytokeratin 5

Learn more about PTMs related to Cytokeratin 5.

Phosphorylation

Bioinformatics Tool for Cytokeratin 5

Discover related pathways, diseases and genes to Cytokeratin 5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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