Cytochrome P450 3A4/3A5 Products

Description

This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.

Bioinformatics

Uniprot	P08684
Product By Gene ID	1576
Alternate Names	Albendazole monooxygenase Albendazole sulfoxidase CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 Cytochrome P450 3A3 cytochrome P450 3A4 Cytochrome P450 HLp Cytochrome P450 NF-25 cytochrome P450, family 3, subfamily A, polypeptide 4 cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 Cytochrome P450-PCN1 EC 1.14.13.32 EC 1.14.13.67 EC 1.14.13.97 EC 1.14.14.1 glucocorticoid-inducible P450 HLP MGC126680 NF-25 Nifedipine oxidase P450C3 P450-III, steroid inducible P450PCN1 Quinine 3-monooxygenase Taurochenodeoxycholate 6-alpha-hydroxylase

Research Areas for Cytochrome P450 3A4/3A5

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism