CXCL12/SDF-1 gamma Products

Description

CXCL12 also known as SDF1 is belonging to the CXC chemokine family. It is encoded by the CXCL12 gene. In recently study, Human CXCL12 is expressed as six isoforms that differ only in the Cterminal tail. And all SDF1 isoforms undergo proteolytic processing of the first two Nterminal amino acids. Human SDF1gamma is synthesized as a 119 amino acid (a.a.) precursor that contains a 21 a.a. signal sequence and a 98 a.a. mature region and the SDF1gamma Cterminus binds heparin in secreted SDF1gamma, or targets the isoform to the nucleolus in the absence of a signal sequence. On the cell surface, the receptor for this chemokine is CXCR4 and syndecan4. CXCL12 is strongly chemotactic for Tlymphocytes, monocytes, but not neutrophils. CXCL12 is a very important factor in carcinogenesis and the neovascularisation linked to tumor progression.

Bioinformatics

Uniprot	P48061 P48061 P48061
Product By Gene ID	6387
Alternate Names	CXCL12/SDF-1 gamma SDF1 gamma SDF1g