Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.
Bioinformatics
| Entrez |
Mouse
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
1434 |
| Alternate Names |
- CASMGC117283
- Cellular apoptosis susceptibility protein
- chromosome segregation 1 (yeast homolog)-like
- Chromosome segregation 1-like protein
- CSE1 chromosome segregation 1-like (yeast)
- CSE1
- CSE1L
- Exp2
- exp2
- exportin-2
- Importin-alpha re-exporter
- MGC130037
- XPO2MGC130036
|
