COQ3 Products

Description

Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM]

Bioinformatics

Entrez	51805 Human
Uniprot	AAH63463.1 Human NM_017421 Human NP_059117 Human
Product By Gene ID	51805
Alternate Names	3-demethylubiquinone-10 3-methyltransferase bA9819.1 coenzyme Q3 homolog, methyltransferase (S. cerevisiae) coenzyme Q3 homolog, methyltransferase (yeast) DHHB methyltransferase DHHBMT DHHB-MT DHHBMTASE DHHB-MTase Dihydroxyhexaprenylbenzoate methyltransferase EC 2.1.1 EC 2.1.1.114 EC 2.1.1.64 hexaprenyldihydroxybenzoate methyltransferase, mitochondrial3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase methyltransferase COQ3 UG0215E05

Research Areas for COQ3

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Core ESC-Like Genes
Stem Cell Markers