COP1 Products

COP1 Antibody (1E4)
COP1 Antibody (1E4)
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
COP1 Knockout HeLa Cell Lysat ...
COP1 Knockout HeLa Cell Lysate
Species: Hu
Applications: WB
COP1 Overexpression Lysate
COP1 Overexpression Lysate
Species: Hu
Applications: WB
COP1 Overexpression Lysate
COP1 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human COP1 Protei ...
Recombinant Human COP1 Protein
Species: Hu
Applications: WB, ELISA, PA, AP


COP1 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. It is directly involved in p53 ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. It ubiquitinates p53 independently of MDM2 or RCHY1. It probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, where the ubiquitin ligase activity is mediated by RBX1.


Entrez Human
Uniprot Human
Product By Gene ID 64326
Alternate Names
  • EC 6.3.2.-
  • RING finger and WD repeat domain protein 2
  • putative ubiquitin ligase COP1
  • hCOP1
  • E3 ubiquitin-protein ligase RFWD2
  • Constitutive photomorphogenesis protein 1 homolog
  • constitutive photomorphogenic protein (COP1)
  • COP1RNF200FLJ10416
  • RING finger protein 200
  • ring finger and WD repeat domain 2

Research Areas for COP1

Find related products by research area and learn more about each of the different research areas below.

p53 Pathway
Zinc Finger

Bioinformatics Tool for COP1

Discover related pathways, diseases and genes to COP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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