COP1 Products

Description

COP1 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. It is directly involved in p53 ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. It ubiquitinates p53 independently of MDM2 or RCHY1. It probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, where the ubiquitin ligase activity is mediated by RBX1.

Bioinformatics

Entrez	64326 Human
Uniprot	NP_001001740 Human NP_071902 Human Q8NHY2 Human
Product By Gene ID	64326
Alternate Names	Constitutive photomorphogenesis protein 1 homolog constitutive photomorphogenic protein (COP1) COP1RNF200FLJ10416 E3 ubiquitin-protein ligase RFWD2 EC 6.3.2.- hCOP1 putative ubiquitin ligase COP1 ring finger and WD repeat domain 2 RING finger and WD repeat domain protein 2 RING finger protein 200

Research Areas for COP1

Find related products by research area and learn more about each of the different research areas below.

p53 Pathway
Zinc Finger