COP1 Products

Antibodies
COP1 Antibody (1E4)
COP1 Antibody (1E4)
H00064326-M01
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Lysates
COP1 Overexpression Lysate (N ...
COP1 Overexpression Lysate (Native)
NBP2-06435
Applications: WB
COP1 Overexpression Lysate (N ...
COP1 Overexpression Lysate (Native)
NBP2-10727
Applications: WB
Proteins
COP1 Partial Recombinant Prot ...
COP1 Partial Recombinant Protein
H00064326-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
COP1 RNAi
COP1 RNAi
H00064326-R01
Species: Hu
Applications: RNAi, RNAi SP
COP1 RNAi
COP1 RNAi
H00064326-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

COP1 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. It is directly involved in p53 ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. It ubiquitinates p53 independently of MDM2 or RCHY1. It probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, where the ubiquitin ligase activity is mediated by RBX1.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 64326
Alternate Names
  • EC 6.3.2.-
  • RING finger and WD repeat domain protein 2
  • putative ubiquitin ligase COP1
  • hCOP1
  • E3 ubiquitin-protein ligase RFWD2
  • Constitutive photomorphogenesis protein 1 homolog
  • constitutive photomorphogenic protein (COP1)
  • COP1RNF200FLJ10416
  • RING finger protein 200
  • ring finger and WD repeat domain 2

Research Areas for COP1

Find related products by research area and learn more about each of the different research areas below.

p53 Pathway
Zinc Finger

Bioinformatics Tool for COP1

Discover related pathways, diseases and genes to COP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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