Complement C8A Products

Lysates
Complement C8A Overexpression ...
Complement C8A Overexpression Lysa...
NBP2-09010
Applications: WB

Description

C8 is synthesized in the liver, monocytes and fibroblasts and is a plasma protein consisting of three non identical polypeptide chains. The alpha-chain (64kDa) and gamma chain (22kDa) are disulphide linked, these associate non-covalently with the beta-chain (64kDa), to form the native C8 molecule with a molecular weight of 151kDa. Normal plasma concentration is 80mg/L. C8 is one of the terminal proteins of the complement pathways. C8 binds to the membrane bound C5b-7, C5b-8 combines with C9 to form the membrane attack complex (MAC). The MAC forms a hydrophilic, protein walled, transmembrane channel, formation of which leads to cell lysis and destruction. C8 is synthesized in the liver, monocytes and fibroblasts and is a plasma protein consisting of three non identical polypeptide chains. The alpha-chain (64kDa) and gamma chain (22kDa) are disulphide linked, these associate non-covalently with the beta-chain (64kDa), to form the native C8 molecule with a molecular weight of 151kDa. Normal plasma concentration is 80mg/L. C8 is one of the terminal proteins of the complement pathways. C8 binds to the membrane bound C5b-7, C5b-8 combines with C9 to form the membrane attack complex (MAC). The MAC forms a hydrophilic, protein walled, transmembrane channel, formation of which leads to cell lysis and destruction.

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 731
Alternate Names
  • complement component C8 alpha chain
  • complement component 8, alpha polypeptide

Pathways for Complement C8A

View related products by pathway and learn more about each of the pathways below.

Complement Activation
Disease Resistance
Neuroprotection
Dna Replication
Acute-phase Response
Immune Response
Pathogenesis
Viral Replication
Localization

PTMs for Complement C8A

Learn more about PTMs related to Complement C8A.

Phosphorylation
Glycosylation
Acetylation
Oxidation
Methylation
Deamidation

Bioinformatics Tool for Complement C8A

Discover related pathways, diseases and genes to Complement C8A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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