Clusterin/APOJ Products

Description

Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP-40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid poly-peptide that is posttranslationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, alpha and beta, are associated through disulfide bonds. The beta subunit (also called ApoJalpha) corresponds to residues 23-227. The alpha subunit (also called ApoJbeta) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences beta-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer's disease pathogenesis.

Bioinformatics

Entrez	1191 Human
Uniprot	NP_001822
Product By Gene ID	1191
Alternate Names	40 40, sulfated glycoprotein 2 Aging-associated gene 4 protein aging-associated protein 4 APOJ Apo-J Apolipoprotein J CLI CLIclusterin (complement lysis inhibitor, SP-40 CLU Clusterin Complement cytolysis inhibitor complement lysis inhibitor Complement-associated protein SP-40 Ku70-binding protein 1 KUB1SGP2 MGC24903 NA1/NA2 SGP-2 SP-40 sulfated glycoprotein 2 Testosterone-repressed prostate message 2 testosterone-repressed prostate message 2, apolipoprotein J) TRPM-2 TRPM-2TRPM2

Research Areas for Clusterin/APOJ

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
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Cytokine Research
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Immunology
Innate Immunity