CLCN6 Products

Antibodies
CLCN6 Antibody (2H2)
CLCN6 Antibody (2H2)
H00001185-M05
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
CLCN6 Antibody
CLCN6 Antibody
NBP1-85583
Species: Hu, Mu, Rt
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
Recombinant Human CLCN6 Prote ...
Recombinant Human CLCN6 Protein
H00001185-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human CLCN6 Prote ...
Recombinant Human CLCN6 Protein
H00001185-Q01
Species: Hu
Applications: WB, ELISA, PA
CLCN6 Recombinant Protein Ant ...
CLCN6 Recombinant Protein Antigen
NBP1-85583PEP
Species: Hu
Applications: AC
RNAi
CLCN6 RNAi
CLCN6 RNAi
H00001185-R02
Species: Hu
Applications: RNAi, RNAi SP
CLCN6 RNAi
CLCN6 RNAi
H00001185-R01
Species: Hu
Applications: RNAi, RNAi SP
CLCN6 RNAi
CLCN6 RNAi
H00001185-R04
Species: Hu
Applications: RNAi, RNAi SP

Description

The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7, 3q26, 4q32, Xp22, Xp11, 1p36 and 16p13, respectively. CLC-1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC-1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC-2 is highly expressed in the epithelia of several organs including lung, which suggests CLC-2 may be a possible therapeutic target for cystic fibrosis. CLC-3 expression is particularly abundant in neuronal tissue, while CLC-4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC-5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC-6 and CLC-7 are broadly expressed in several tissues including testes, kidney, brain and muscle.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 1185
Alternate Names
  • ClC-6
  • chloride transport protein 6
  • Chloride channel protein 6
  • KIAA0046CLC-6
  • chloride channel 6

PTMs for CLCN6

Learn more about PTMs related to CLCN6.

Glycosylation
Cleavage
Methylation

Bioinformatics Tool for CLCN6

Discover related pathways, diseases and genes to CLCN6. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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