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CISH is encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor.
![Western Blot CISH/CIS-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/CIS-1_AF3194_Western_Blot_5249.jpg)
![Western Blot CISH/CIS-1 Antibody (989616) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/CIS1_MAB3194_Western_Blot_22247.jpg)
![Immunocytochemistry CISH/CIS-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af3194_human-cis-1-affinity-purified-polyclonal-ab-immunocytochemistry-309202194844.jpg)
![Simple Western CISH/CIS-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af3194_human-cis-1-affinity-purified-polyclonal-ab-simple-western-1342022124434.jpg)
