cGK1/PRKG1 Products

Antibodies
cGK1/PRKG1 Antibody (9G4)
cGK1/PRKG1 Antibody (9G4)
NBP2-02521
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
cGK1/PRKG1 Antibody
cGK1/PRKG1 Antibody
NBP2-14843
Species: Hu, Mu, Rt, Bv
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
cGK1/PRKG1 Antibody
cGK1/PRKG1 Antibody
NBP1-87289
Species: Hu, Mouse, Rat
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
cGK1/PRKG1 Overexpression Lys ...
cGK1/PRKG1 Overexpression Lysate (...
NBL1-14782
Applications: WB
cGK1/PRKG1 Overexpression Lys ...
cGK1/PRKG1 Overexpression Lysate (...
H00005592-T01
Applications: WB
Proteins
cGK1/PRKG1 Partial Recombinan ...
cGK1/PRKG1 Partial Recombinant Pro...
H00005592-Q01
Species: Hu
Applications: WB, ELISA, PA
cGK1/PRKG1 Recombinant Protei ...
cGK1/PRKG1 Recombinant Protein
H00005592-P01
Species: Hu
Applications: WB, ELISA, PA
cGK1/PRKG1 Recombinant Protei ...
cGK1/PRKG1 Recombinant Protein Ant...
NBP1-87289PEP
Species: Hu
Applications: AC
RNAi
cGK1/PRKG1 RNAi
cGK1/PRKG1 RNAi
H00005592-R02
Species: Hu

Description

cGK1/PRKG1, also known as cGMP-dependent protein kinase 1, has two isoforms that are produced by alternative splicing. Isoform Alpha (CGK1-alpha) is 671 amino acids long and 76 kDa. Isoform Beta (CGK1-beta) is 686 amino acids long and approximately 78 kDa. PRKG1 is a Serine/threonine protein kinase that is expressed in placenta and lung. cGK1/PRKG1 is an important player in the Nitric Oxide/cGMP Signaling Pathway; the binding of GMP activates PRKG1, which in turn phosphorylates Serine residues and Threonine residues on various cell proteins, including proteins that regulate calcium levels, smooth muscle contraction, platelet adhesion, circadian rhythm and more. Current research on PRKG1 is being conducted in relation to several diseases and disorders including cystic fibrosis, lymphoma, non-small cell lung carcinoma, Wiskott-Aldrich syndrome, Waterhouse-Friderichsen syndrome and myoglobinuria. PRKG1 has also been shown to have interactions with SMAD4, BMPR2, GKAP1, Natriuretic Peptide Receptor A and TFII-I in pathways such as Gap Junction signaling, eNOS signaling and EDNRB signaling.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 5592
Alternate Names
  • DKFZp686K042
  • EC 2.7.11
  • CGKI
  • cGKI
  • EC 2.7.11.12
  • PRKGR1A
  • cGMP-dependent protein kinase I
  • PRKGR1BcGMP-dependent, regulatory, type I, beta
  • PRKG1BMGC71944
  • FLJ36117
  • protein kinase, cGMP-dependent, type I

Research Areas for cGK1/PRKG1

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase

Bioinformatics Tool for cGK1/PRKG1

Discover related pathways, diseases and genes to cGK1/PRKG1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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