CEP170 Products

Description

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.

Bioinformatics

Entrez	9859 Human
Uniprot	NP_055627 Human NP_055627.2 Human Q5SW79 Human
Product By Gene ID	9859
Alternate Names	centrosomal protein 170kDa Cep170 KARP 1 binding protein KARP-1-binding protein KARP1-binding protein KIAA0470FAM68AKABcentrosomal protein of 170 kDa XRCC5 binding protein