CDT1 Products

Antibodies
CDT1 Antibody
CDT1 Antibody
NB100-2567
Species: Hu, Primate
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
CDT1 Antibody
CDT1 Antibody
NBP1-58114
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
CDT1 Antibody
CDT1 Antibody
NB100-1098
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
Lysates
CDT1 Overexpression Lysate (N ...
CDT1 Overexpression Lysate (Native)
NBL1-09063
Applications: WB

Description

Geminin is a protein that inhibits DNA replication by preventing the loading of MCM complex on chromatin. Human CDT1 is a 65kDa protein that contains 546 amino acids and coimmunoprecipitates with Geminin. Inhibition of DNA replication by Geminin in cell-free cDNA replication extracts can be reversed by the addition of excess CDT1. In the normal cell cycle, CDT1 is present only in G1 and S phases, whereas Geminin is present in S and G2 phases. Wohlschlegel et al. (2000) concluded that their results suggest that Geminin inhibits inappropriate origin firing by targeting CDT1. This antibody was raised by a genetic immunization technique. Genetic immunization can be used to generate antibodies by directly delivering antigen-coding DNA into the animal, rather than injecting a protein or peptide (Tang et al. PubMed: 1545867; Chambers and Johnston PubMed 12910245; Barry and Johnston PubMed: 9234514). The animals cells produce the protein, which stimulates the animals immune system to produce antibodies against that particular protein. A vector coding for a partial fusion protein was used for genetic immunisation of a mouse and the resulting serum was tested in Western blot against an E.coli lysate containing that partial fusion protein. Genetic immunization offers enormous advantages over the traditional protein-based immunization method. DNA is faster, cheaper and easier to produce and can be produced by standard techniques readily amenable to automation. Furthermore, the antibodies generated by genetic immunization are usually of superior quality with regard to specificity, affinity and recognizing the native protein.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 81620
Alternate Names
  • Double parked, Drosophila, homolog of
  • DNA replication factor Cdt1
  • Double parked homolog
  • DUPRIS2
  • chromatin licensing and DNA replication factor 1

Bioinformatics Tool for CDT1

Discover related pathways, diseases and genes to CDT1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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