Cdk9 Products

Antibodies
Cdk9 Antibody
Cdk9 Antibody
NB120-10874
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Cdk9 Antibody
Cdk9 Antibody
NBP2-15848
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Cdk9 Antibody (1B5A7)
Cdk9 Antibody (1B5A7)
NBP2-37601
Species: Hu
Applications: WB, ELISA, IHC
Host: Mouse Monoclonal
Proteins
Cdk9 Partial Recombinant Prot ...
Cdk9 Partial Recombinant Protein
H00001025-Q01
Species: Hu
Applications: WB, ELISA, PA
Cdk9 Recombinant Protein
Cdk9 Recombinant Protein
H00001025-P01
Species: Hu
Applications: WB, ELISA, PA
Cdk9 Recombinant Protein Anti ...
Cdk9 Recombinant Protein Antigen
NBP1-86808PEP
Species: Hu
Applications: AC
RNAi
Cdk9 RNAi
Cdk9 RNAi
H00001025-R02
Species: Hu

Description

CDK9 (PITALRE) (also known as cyclin-dependent kinase 9, Serine/threonine-protein kinase PITALRE, C-2K and Cell division cycle 2-like protein kinase 4) is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. CDK9 (PITALRE) interacts with a conserved domain in the TRAF-C region of the tumor necrosis factor signal transducer TRAF2. This kinase also was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. Tat stimulates human HIV-1 viral transcription elongation. This suggests that cyclin T1/cdk9(PITALRE) is one of the HIV-1 required host cellular cofactors generated during T cell activation. Cyclin T1/cdk9(PITALRE) is shown to interact with Tat to restore Tat activation in HeLa nuclear extracts depleted of P-TEFb. The cdk9(PITALRE) activity and cyclin T1 are essential for activation of transcription when tethered to the heterologous Rev response element RNA via the regulator of expression of virion Rev. CDK9 (PITALRE) is a ubiquitously expressed nuclear protein.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 1025
Alternate Names
  • EC 2.7.11
  • Serine/threonine-protein kinase PITALRE
  • EC 2.7.11.23
  • Cell division protein kinase 9
  • EC 2.7.11.22
  • Cell division cycle 2-like protein kinase 4
  • C-2K
  • TAK
  • serine/threonine protein kinase PITALRE
  • PITALRE
  • CDC2-related kinase
  • C-2k
  • CDC2L4CTK1
  • cyclin-dependent kinase 9 (CDC2-related kinase)
  • cyclin-dependent kinase 9

Research Areas for Cdk9

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Phospho-Specific
Signal Transduction
Virology, Bacteria and Parasites

Bioinformatics Tool for Cdk9

Discover related pathways, diseases and genes to Cdk9. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.