CD300a/LMIR1 Products

Description

Human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), is a 60kDa transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.

Bioinformatics

Entrez	11314 Human
Uniprot	AAH32352 Human Q9UGN4 Human NP_009192 Human NP_009192.2 Human
Product By Gene ID	11314
Alternate Names	CMRF35-H9 IgSF12 CMRF35-H leukocyte membrane antigen CLM-8 CMRF35H leukocyte immunoglobulin-like receptor Inhibitory receptor protein 60 CMRF35-like molecule 8 Immunoglobulin superfamily member 12 CMRF-35H IRC2 Irp60 IRC1 CD300a antigenCMRF35H9 IGSF12NK inhibitory receptor CMRF-35-H9CD300 antigen-like family member A CMRF35HIRp60 IRC1/IRC2 CD300a molecule

Diseases related to CD300a/LMIR1

Discover more about diseases related to CD300a/LMIR1.

Inflammation
Allergy
Anaphylaxis
Chronic Eosinophilic Inflammation
Leukemia
Cutaneous Anaphylaxis (disorder)
Cholangiocarcinoma
Tetanus
Polyps
Ulcer
Immunologic Deficiency Syndromes
Neoplasm, Residual
Neoplasms
Asthma
L1 Acute Lymphoblastic Leukemia
Diarrhea
Peritonitis
Hay Fever
Eosinophilia

Pathways for CD300a/LMIR1

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Basophil Degranulation
Anaphylaxis
Phagocytosis
Eosinophil Activation
Signal Transmission
Immune Response
Fibroblast Proliferation
Conjugation
Macrophage Activation
Mast Cell Degranulation
Cell Death
Tissue Remodeling
Basophil Activation
Secretion

Research Areas for CD300a/LMIR1

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Mast Cell Markers

PTMs for CD300a/LMIR1

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Phosphorylation

Bioinformatics Tool for CD300a/LMIR1

Discover related pathways, diseases and genes to CD300a/LMIR1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.