Species: Hu
Applications: WB, ELISA
Host: Goat Polyclonal
Species: Mu
Applications: Flow, CyTOF-ready
Host: Rat Monoclonal
Species: Hu
Applications: WB, Flow, CyTOF-ready
Host: Rat Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Mu
Applications: Bioactivity
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: AC
Description
Human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), is a 60kDa transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.
Bioinformatics
Entrez |
Human |
Uniprot |
Human Human Human Human |
Product By Gene ID |
11314 |
Alternate Names |
- CD300a antigenCMRF35H9
- CD300a molecule
- CLM-8
- CMRF35H leukocyte immunoglobulin-like receptor
- CMRF-35H
- CMRF35-H
- CMRF35-H9
- CMRF-35-H9CD300 antigen-like family member A
- CMRF35HIRp60
- CMRF35-like molecule 8
- IgSF12
- IGSF12NK inhibitory receptor
- Immunoglobulin superfamily member 12
- Inhibitory receptor protein 60
- IRC1
- IRC1/IRC2
- IRC2
- Irp60
- leukocyte membrane antigen
|
Research Areas for CD300a/LMIR1
Find related products by research area and learn more about each of the different research areas below.
Mast Cell Markers