CD300a/LMIR1 Products

Description

Human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), is a 60kDa transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.

Bioinformatics

Entrez	11314 Human
Uniprot	AAH32352 Human NP_009192 Human NP_009192.2 Human Q9UGN4 Human
Product By Gene ID	11314
Alternate Names	CD300a antigenCMRF35H9 CD300a molecule CLM-8 CMRF35H leukocyte immunoglobulin-like receptor CMRF-35H CMRF35-H CMRF35-H9 CMRF-35-H9CD300 antigen-like family member A CMRF35HIRp60 CMRF35-like molecule 8 IgSF12 IGSF12NK inhibitory receptor Immunoglobulin superfamily member 12 Inhibitory receptor protein 60 IRC1 IRC1/IRC2 IRC2 Irp60 leukocyte membrane antigen

Research Areas for CD300a/LMIR1

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Mast Cell Markers