CD300a/LMIR1 Products

Antibodies
ELISA Kits
Human CD300a/LMIR1 DuoSet ELI ...
Human CD300a/LMIR1 DuoSet ELISA, 5...
DY2640-05
Species: Hu
Applications: ELISA
Lysates
CD300a/LMIR1 Overexpression L ...
CD300a/LMIR1 Overexpression Lysate
NBP2-07516
Species: Hu
Applications: WB
Proteins
Recombinant Mouse CD300a/LMIR ...
Recombinant Mouse CD300a/LMIR1 Fc ...
1186-LM
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human CD300a/LMIR ...
Recombinant Human CD300a/LMIR1 Fc ...
2640-LM
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
CD300a/LMIR1 Recombinant Prot ...
CD300a/LMIR1 Recombinant Protein A...
NBP1-84431PEP
Species: Hu
Applications: AC

Description

Human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), is a 60kDa transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 11314
Alternate Names
  • CD300a antigenCMRF35H9
  • CD300a molecule
  • CLM-8
  • CMRF35H leukocyte immunoglobulin-like receptor
  • CMRF-35H
  • CMRF35-H
  • CMRF35-H9
  • CMRF-35-H9CD300 antigen-like family member A
  • CMRF35HIRp60
  • CMRF35-like molecule 8
  • IgSF12
  • IGSF12NK inhibitory receptor
  • Immunoglobulin superfamily member 12
  • Inhibitory receptor protein 60
  • IRC1
  • IRC1/IRC2
  • IRC2
  • Irp60
  • leukocyte membrane antigen

Research Areas for CD300a/LMIR1

Find related products by research area and learn more about each of the different research areas below.

Mast Cell Markers