CD-M6PR Products

Antibodies
CD-M6PR Antibody
CD-M6PR Antibody
AF5320
Species: Hu
Applications: WB
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
CD-M6PR Antibody
CD-M6PR Antibody
NB100-93413
Species: Hu, Mu, Rt, Bv, Ca
Applications: PEP-ELISA
Host: Goat Polyclonal
CD-M6PR Antibody
CD-M6PR Antibody
NB100-75286
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Chicken Polyclonal
Lysates
CD-M6PR Overexpression Lysate ...
CD-M6PR Overexpression Lysate (Nat...
NBP2-10825
Applications: WB
Proteins
CD-M6PR Recombinant Protein A ...
CD-M6PR Recombinant Protein Antigen
NBP2-38467PEP
Species: Hu
Applications: AC
CD-M6PR Recombinant Protein
CD-M6PR Recombinant Protein
NBP2-51688
Species: Hu
Applications: PAGE
RNAi
CD-M6PR RNAi
CD-M6PR RNAi
H00004074-R01
Species: Hu

Description

Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of 300 kDa cation independent mannose 6-phospate receptors (CI-MPR). The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and ~10 % at cell surface. In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An ~240 kDa soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.

Bioinformatics

Entrez Human
Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 4074
Alternate Names
  • M6PR
  • MPRD
  • MPR 46
  • 000 Man6PR
  • Mr 46
  • CD Man-6-P receptor
  • cation-dependent mannose-6-phosphate receptor
  • MPR46
  • SMPR
  • CD-MPR
  • FLJ32994
  • 46 kDa mannose 6-phosphate receptor
  • 46-kDa mannose 6-phosphate receptor
  • mannose-6-phosphate receptor (cation dependent)

PTMs for CD-M6PR

Learn more about PTMs related to CD-M6PR.

Phosphorylation
Cleavage
Glycosylation

Bioinformatics Tool for CD-M6PR

Discover related pathways, diseases and genes to CD-M6PR. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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