CD-M6PR Products

Description

Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of 300 kDa cation independent mannose 6-phospate receptors (CI-MPR). The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and ~10 % at cell surface. In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An ~240 kDa soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.

Bioinformatics

Entrez	17113 Mouse 312689 Rat 3482 Human 4074 Human
Uniprot	NP_002346 Human NP_002346.1 Human P20645 Human
Product By Gene ID	4074
Alternate Names	000 Man6PR 46 kDa mannose 6-phosphate receptor 46-kDa mannose 6-phosphate receptor cation-dependent mannose-6-phosphate receptor CD Man-6-P receptor CD-MPR FLJ32994 M6PR mannose-6-phosphate receptor (cation dependent) MPR 46 MPR46 MPRD Mr 46 SMPR