Cathepsin F Products

Description

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.

Bioinformatics

Entrez	8722 Human
Uniprot	NP_003784 Human NP_003784.2 Human Q9UBX1 Human Q9WUT4 Mouse
Product By Gene ID	8722
Alternate Names	EC 3.4.22 CATSFEC 3.4.22.41 cathepsin F

Diseases related to Cathepsin F

Discover more about diseases related to Cathepsin F.

Malignant Neoplasms
Neoplasms
Cell Invasion
Atherosclerosis
Adenovirus Infections
Cholangiocarcinoma
Neoplasm Metastasis
Tumor Progression
Weakness
Neurodegenerative Disorders
Uterine Cervical Neoplasm
Neuromuscular Diseases
Neoplasm Invasiveness
Malignant Tumor Of Cervix
Carcinoma
Osteosarcoma
Fibrosis

Pathways for Cathepsin F

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Immune Response
Localization
Cell Activation
Cell Migration
Endocytosis
Translation
Cholesterol Efflux
Regulation Of Hepatic Stellate Cell Activation
Angiogenesis
Wound Healing
Hepatic Stellate Cell Activation
Pathogenesis
Secretion

Research Areas for Cathepsin F

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Immunology

PTMs for Cathepsin F

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Phosphorylation
Phosphorothioation
Glycosylation
Cleavage

Bioinformatics Tool for Cathepsin F

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