Calpastatin Products

Antibodies
Calpastatin Antibody (2G11D6) ...
Calpastatin Antibody (2G11D6)
NB120-3515
Species: Hu, Rt, Po, Bv, Ca, Fi, Rb
Applications: WB, IHC, IHC-Fr, IHC-P, ICC
Host: Mouse Monoclonal
Calpastatin Antibody (1E7)
Calpastatin Antibody (1E7)
NBP2-01819
Species: Hu
Applications: WB, Flow, IHC, IHC-P
Host: Mouse Monoclonal
Calpastatin Antibody (1F7E3D1 ...
Calpastatin Antibody (1F7E3D10)
NB120-5582
Species: Hu, Rt, Po, Bv
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Antibody Pairs
Calpastatin Antibody Pair
Calpastatin Antibody Pair
H00000831-AP22
Species: Hu
Applications: S-ELISA
Lysates
Calpastatin Overexpression Ly ...
Calpastatin Overexpression Lysate ...
H00000831-T01
Species: Hu
Applications: WB
Calpastatin Overexpression Ly ...
Calpastatin Overexpression Lysate ...
NBL1-08722
Applications: WB
Proteins
Recombinant Human Calpastatin ...
Recombinant Human Calpastatin Protein
H00000831-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human Calpastatin ...
Recombinant Human Calpastatin Protein
H00000831-Q01
Species: Hu
Applications: WB, ELISA, PA
Calpastatin Recombinant Prote ...
Calpastatin Recombinant Protein An...
NBP2-38336PEP
Species: Hu
Applications: AC

Description

The calpain system has been detected in every vertebrate tissue examined, and has been suggested to play a regulatory role in cellular protein metabolism. This regulatory role may have important implications in platelet aggregation and pathologies associated with altered calcium homeostasis and protein metabolism such as ischemic cell injury and degenerative diseases. Inhibitors of calpain have been shown to block dexamethasone and low-level irradiation induced apoptosis in thymocytes suggesting that calpain has a regulatory or mechanistic role in apoptotic cell death.Calpastatin, a specific endogenous inhibitor of calpain, has a predicted molecular weight of ~77 kDa and an internal repeat of four homologous domains which allow it to inhibit multiple calpain molecules simultaneously. It functions by binding to calpain when calpain binds calcium. When Calpastatin is subjected to proteolytic digestion, fragments of calpastatin as small as 15 kDa still retain inhibitory activity.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Human
Bovine
Product By Gene ID 831
Alternate Names
  • MGC9402
  • BS-17
  • Sperm BS-17 component
  • Calpain inhibitor
  • calpastatin

Research Areas for Calpastatin

Find related products by research area and learn more about each of the different research areas below.

Hypoxia
Neuroscience

Bioinformatics Tool for Calpastatin

Discover related pathways, diseases and genes to Calpastatin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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