BNIP3 Products

Description

BCL2/adenovirus E1B 19kD protein-interacting protein 3 (BNIP3) is a mitochondrial protein critical for apoptotic events in response to adenovirus infection. It has been implicated in causing a necrotic-like cell death pattern in cells, induced by CD47. This effect has been seen in many cancer cells, and its mis-regulation causes tumor cells to be impervious to normal autophagic events. The tumor suppressor p53 represses the expression of BNIP3, often as a consequence of hypoxic micro-environments as seen in tumors. When BNIP3 is correctly expressed and activated, it translocates to the mitochondria and instigates apoptosis.

Bioinformatics

Product By Gene ID	664
Alternate Names	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 BCL2/adenovirus E1B 19kDa interacting protein 3 BCL2/adenovirus E1B 19kD-interacting protein 3 BNIP3 Nip3

Research Areas for BNIP3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Autophagy
Cancer
Hypoxia
Tumor Suppressors

Related BNIP3 Blog Posts

Check out the latest blog posts on BNIP3.

BNIP3 - a regulator of mitochondrial autophagy and cell death Bcl-2 nineteen-kilodalton interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein. BNIP3 localizes to the mitochondrial membrane where it plays a key role in mitochondrial autophagy and cell death pathways. Similar to other Bcl-2 family m...    Read more.

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