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3209-BP) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Alkaline phosphatase production elicited by Recombinant Human BMP-9 (5 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human/Mouse/Primate BMP-9 Monoclonal Antibody (Catalog # MAB3209). The ND50 is typically 0.01-0.04 µg/mL." class="big_lightbox" target="_blank">
3209-BP) was serially diluted and captured by Mouse Anti-Human/Mouse/Primate BMP‑9 Monoclonal Antibody (Catalog # MAB3209) coated on a Clear Polystyrene Microplate (Catalog # DY990). Goat Anti-Human/Mouse BMP‑9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3209) was biotinylated and incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (Catalog # DY998)" class="big_lightbox" target="_blank">
3209-BP) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Alkaline phospha-tase production elicited by Recombinant Human BMP-9 (2 ng/mL) is neutralized (green line) by increasing concen-trations of Goat Anti-Human BMP-9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3209). The ND50 is typically 0.005-0.1 µg/mL." class="big_lightbox" target="_blank">
3209-BP) was serially diluted and captured by Mouse Anti-Human/Mouse/Primate BMP‑9 Monoclonal Antibody (Catalog # MAB3209) coated on a Clear Polystyrene Microplate (Catalog # DY990). Goat Anti-Human/Mouse BMP‑9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3209) was biotinylated and incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (Catalog # DY998)" class="big_lightbox" target="_blank">
Bone Morphogenetic Proteins (BMPs) are members of the TGF beta superfamily of cytokines that affect bone and cartilage formation. Similar to other TGF beta family proteins, BMPs are highly conserved across animal species. Mature BMPs are 30-38 kDa proteins that assume a TGF beta like cysteine knot configuration. Unlike TGF beta, BMPs do not form latent complexes with their propeptide counterparts. Most BMPs are homodimers, but bioactive natural heterodimers have been reported. Recently it was found that lovostatin, widely used for lowering cholesterol, also increases bone formation by turning on a gene (bmp2) that promotes local bone formation. BMPs create an environment conducive for bone marrow development by stimulating the production of specific bone matrix proteins and altering stromal cell and osteoclast proliferation. In addition to stimulating ectopic bone and cartilage development, BMPs may be an important factor in the development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis. BMPs also appear to be responsible for normal dorsal/ventral patterning. BMPs are found in tissues that induce bone or cartilage growth, such as demineralized bone and urinary epithelium. Cellular responses to BMP5 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors which play significant roles in BMP binding and signaling. One BMP type II receptor and two BMP type I receptors have been identified.
![Neutralization BMP-9 Antibody (360107) [Unconjugated]](http://images.novusbio.com/images/antibody/BMP-9_MAB3209_Block_Neutralize_9144.jpg)
![Neutralization BMP-9 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/BMP-9_AF3209_Block_Neutralize_8847.jpg)
![N/A BMP-9 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_BMP9_DY3209_ELISA_1926.jpg)
![N/A BMP-9 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_BMP9_DY5566_ELISA_2119.jpg)
![Bioactivity BMP-9 [Unconjugated]](http://images.novusbio.com/fullsize/protein/BMP9_9624BP_1656.jpg)
![Western Blot BMP-9 Antibody (360107) [Unconjugated]](http://images.novusbio.com/fullsize/mab3209_human-mouse-primate-bmp-9-mab-clone-360107-8120255541717.jpg)
![ELISA BMP-9 Antibody (360107) [Unconjugated]](http://images.novusbio.com/images/mab3209_human-mouse-primate-bmp-9-mab-clone-360107-elisa-639201777770177814.jpg)
![ELISA BMP-9 Antibody [Unconjugated]](http://images.novusbio.com/images/af3209_human-mouse-bmp-9-affinity-purified-polyclonal-ab-elisa-639201850085309738.jpg)
