BLTP2 Products

Description

This gene was initially characterized in human as having high expression levels in breast carcinomas and breast cancer cell lines. This gene also has increased expression in prostrate cancer cells relative to normal prostrate tissues. Expression of this gene is negatively regulated by direct binding of the microRNA miR-195 to its 3' UTR. miR-195 has been shown to modulate the invasiveness of prostrate cancer cells and xenograft metastases by downgrading expression of this gene. In mouse, the protein encoded by this gene was identified as an antigen on acute monocytic leukemia cells. In human, alternative splicing results in multiple transcript variants encoding distinct isoforms; some of these isoforms are predicted to contain an RNA pol II promoter FMP27 protein domain and a Golgi-body-localization APT1 domain.

Bioinformatics

Uniprot	Q14667 Human
Product By Gene ID	9703
Alternate Names	Antigen MLAA-22 BCOX BCOX1 breast cancer overexpressed gene 1 Breast cancer-overexpressed gene 1 protein bridge-like lipid transfer protein family member 2 cancer/testis antigen 101 CT101 DKFZp686M0843 FMP27 Hob hypothetical protein LOC9703 KIAA0100 MGC111488 MGC134981 protein hobbit homolog U937-associated antigen