beta-TrCP1/BTRC Products

Antibodies
beta-TrCP1/BTRC Antibody (763 ...
beta-TrCP1/BTRC Antibody (763524)
MAB7675
Species: Hu
Applications: WB, Simple Western, ICC
Host: Mouse Monoclonal
beta-TrCP1/BTRC Antibody (2H2 ...
beta-TrCP1/BTRC Antibody (2H2)
NBP2-46588
Species: Hu
Applications: WB, Flow, IF
Host: Mouse monoclonal
beta-TrCP1/BTRC Antibody (3D5 ...
beta-TrCP1/BTRC Antibody (3D5)
NBP2-03654
Species: Hu, Mk
Applications: WB, ICC/IF
Host: Mouse Monoclonal
Lysates
beta-TrCP1/BTRC Overexpressio ...
beta-TrCP1/BTRC Overexpression Lys...
NBL1-08055
Applications: WB
Proteins
beta-TrCP1/BTRC Recombinant P ...
beta-TrCP1/BTRC Recombinant Protein
H00008945-P01
Species: Hu
Applications: WB, ELISA, IP, PA

Description

betaTrCP encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway. [provided by RefSeq]

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 8945
Alternate Names
  • F-box and WD repeats protein beta-TrCP
  • F-box/WD repeat-containing protein 1A
  • FBW1A
  • MGC4643
  • E3RSIkappaB
  • FWD1
  • betaTrCP
  • FBXW1
  • beta-TrCP1
  • BETA-TRCP
  • bTrCP1
  • Fwd1
  • bTrCP
  • FBXW1ABTRCP
  • pIkappaBalpha-E3 receptor subunit
  • beta-transducin repeat containing

Research Areas for beta-TrCP1/BTRC

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction
Vision

PTMs for beta-TrCP1/BTRC

Learn more about PTMs related to beta-TrCP1/BTRC.

Phosphorylation
Ubiquitination
Dephosphorylation
Cleavage
Methylation

Bioinformatics Tool for beta-TrCP1/BTRC

Discover related pathways, diseases and genes to beta-TrCP1/BTRC. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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