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The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML) (1-2). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42 (3). Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling (4).
![Western Blot BCR [p Tyr276] Antibody](http://images.novusbio.com/fullsize/Bcr-[p-Tyr276]-Antibody-Western-Blot-NBP2-24460-img0001.jpg)
