BCR Products

Description

The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML) (1-2). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42 (3). Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling (4).

Bioinformatics

Entrez	309696 Rat 613 Human
Uniprot	NP_004318 Human NP_004318.3 Human NP_067585 Human P11274 Human
Product By Gene ID	613
Alternate Names	ALLD22S11 BCR1 breakpoint cluster region protein breakpoint cluster region CMLEC 2.7.11.1 D22S662 PHLFLJ16453 Renal carcinoma antigen NY-REN-26

Research Areas for BCR

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction