BCL2L10 Products

Description

The protein encoded by the BCL2L10 gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. (provided by RefSeq)

Bioinformatics

Entrez	10017 Human
Uniprot	NP_065129 Human NP_065129.1 Human Q9HD36 Human
Product By Gene ID	10017
Alternate Names	Apoptosis regulator Bcl-B apoptotic protein NrH bcl2-L-10 Bcl2-L-10 BCL2-like 10 (apoptosis facilitator) bcl-2-like protein 10 BCLB BCL-B Boo Diva MGC129810 MGC129811

Research Areas for BCL2L10

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Apoptosis