Bcl rambo Products

Antibodies
Bcl rambo Antibody
Bcl rambo Antibody
NBP1-76668
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Bcl rambo Antibody
Bcl rambo Antibody
NB100-56663
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Bcl rambo Antibody
Bcl rambo Antibody
NBP1-90002
Species: Hu, Rat
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Bcl rambo Overexpression Lysa ...
Bcl rambo Overexpression Lysate (N...
NBP2-07183
Applications: WB
Proteins
Bcl rambo Recombinant Protein ...
Bcl rambo Recombinant Protein
H00023786-P01
Species: Hu
Applications: WB, ELISA, PA
Bcl rambo Recombinant Protein ...
Bcl rambo Recombinant Protein Antigen
NBP1-90002PEP
Species: Hu
Applications: AC
Bcl rambo Peptide
Bcl rambo Peptide
NBP1-76668PEP
Species: Hu
Applications: AC

Description

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 23786
Alternate Names
  • Bcl-rambo
  • Bcl2-L-13
  • bcl-2-like protein 13
  • MIL1BCL-RAMBO
  • Protein Mil1
  • BCL2-like 13 (apoptosis facilitator)

Pathways for Bcl rambo

View related products by pathway and learn more about each of the pathways below.

Cell Death
Drug Resistance
Cell Cycle
Cell Growth
Pathogenesis
Localization
Granuloma Formation
Secretion
Autophagy

Research Areas for Bcl rambo

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

PTMs for Bcl rambo

Learn more about PTMs related to Bcl rambo.

Phosphorylation

Bioinformatics Tool for Bcl rambo

Discover related pathways, diseases and genes to Bcl rambo. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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