B3GALT4 Products

Description

B3GALT4 is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. [provided by RefSeq]

Bioinformatics

Entrez	8705 Human
Uniprot	NP_003773 Human NP_003773.1 Human AAH32574 Human NM_003782 Human O96024 Human
Product By Gene ID	8705
Alternate Names	beta3Gal-T4 Gal-T2 EC 2.4.1.62 Beta3GalT4 b3Gal-T4 Beta3Gal-T4 UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase gal-T2 GALT4 beta-3-galactosyltransferase 4 Ganglioside galactosyltransferase beta-1,3-galactosyltransferase 4 Beta-1,3-GalTase 4 GALT2 GalT4 BETA3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4

Diseases related to B3GALT4

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Cholera
Diphtheria

Pathways for B3GALT4

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Glycosylation

PTMs for B3GALT4

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Biotinylation
Glycosylation

Bioinformatics Tool for B3GALT4

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