Aurora B Products

Antibodies
Aurora B Antibody
Aurora B Antibody
NB100-294
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP, MiAr
Host: Rabbit Polyclonal
Aurora B Antibody
Aurora B Antibody
NB500-185
Species: Hu, Primate, Monkey
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Antibody Pairs
Aurora B Antibody Pair
Aurora B Antibody Pair
H00009212-PW1
Species: Hu
Applications: WB, IP
Lysates
Aurora B Overexpression Lysat ...
Aurora B Overexpression Lysate (Na...
NBL1-07860
Applications: WB
Proteins
Aurora B Recombinant Protein
Aurora B Recombinant Protein
NBP1-30242
Species: Hu
Applications: PAGE
RNAi
Aurora B RNAi
Aurora B RNAi
H00009212-R01V
Species: Hu
Applications: WB, RNAi SP
Aurora B RNAi
Aurora B RNAi
H00009212-R02
Species: Hu

Description

Aurora-B is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process. Aurora-B is known to be involved in the regulation of centrosome function, bipolar spindle assembly and chromosome segregation. Aurora kinases are localized at the centrosomes of interphase cells, at the poles of the bipolar spindle and in the midbody of the mitotic apparatus. Substrates identified for the Aurora-B kinases include a kinesin-like motor protein, spindle apparatus proteins, histone H3 protein, kinetochore protein and the tumor suppressor protein p53 (1). Overexpression of aurora B produced multinuclearity and induced aggressive metastasis, suggesting that overexpressed aurora B has multiple functions in cancer development. Identification of Aurora kinases as RasGAP Src homology 3 domain binding protein, also implicates these kinases as potential effectors in the Ras pathway relevant to oncogenesis (2).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 9212
Alternate Names
  • EC 2.7.11
  • Aurora/IPL1-related kinase 2
  • serine/threonine-protein kinase 12
  • Aurora-related kinase 2
  • aurora-B
  • Aurora- and IPL1-like midbody-associated protein 1
  • aurora-1
  • serine/threonine kinase 12
  • aurora kinase B-Sv2
  • STK5
  • aurora kinase B-Sv1
  • IPL1
  • aurkb-sv2
  • AurB
  • STK12aurkb-sv1
  • AIM1Aik2
  • AIK2EC 2.7.11.1
  • AIM-1STK-1
  • ARK2ARK-2
  • aurora kinase BSerine/threonine-protein kinase aurora-B

Research Areas for Aurora B

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
Chromatin Research
Core ESC-Like Genes
DNA Repair
Mitotic Regulators
Phospho-Specific
Stem Cell Markers

PTMs for Aurora B

Learn more about PTMs related to Aurora B.

Phosphorylation
Methylation
Cleavage
Ubiquitination
Glycosylation
Acetylation
Dephosphorylation

Bioinformatics Tool for Aurora B

Discover related pathways, diseases and genes to Aurora B. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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