ATP6V1H Products

Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the regulatory H subunit of the V1 domain which is required for catalysis of ATP but not the assembly of V-ATPase. Three alternatively spliced transcript variants encode two isoforms of the H subunit. [provided by RefSeq]

Bioinformatics

Entrez	51606 Human
Uniprot	NP_057025.2 Human
Product By Gene ID	51606
Alternate Names	ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H CGI-11 MSTP042 NBP1 Nef-binding protein 1 Protein VMA13 homolog SFD SFDalpha SFDbeta vacuolar ATP synthase subunit H vacuolar ATPase subunit H vacuolar proton pump H subunit Vacuolar proton pump subunit H Vacuolar proton pump subunit SFD V-ATPase 50/57 kDa subunits V-ATPase H subunit V-ATPase subunit H VMA13 V-type proton ATPase subunit H