ATP6V1B2 Products

Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq]

Bioinformatics

Entrez	526 Human
Uniprot	AAH03100 Human
Product By Gene ID	526
Alternate Names	000 subunit 56/58kD, isoform 2 ATP6B2ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta polypeptide ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 Endomembrane proton pump 58 kDa subunit H+ transporting two-sector ATPase HO57ATP6B1B2 vacuolar H+-ATPase 56 Vacuolar proton pump subunit B 2 VATB V-ATPase B2 subunit V-ATPase subunit B 2 Vma2 VPP3ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 2 V-type proton ATPase subunit B, brain isoform